Instructor(s): Robert Stroud, Andrej Sali

In this course, we will pursue a qualitative & quantitative understanding of the physical basis of macromolecular function. We will examine: the nature & quantification of the forces that drive macromolecular interactions, both intramolecular (macromolecular folding), & with other proteins and ligands; diffusion & active transport of macromolecules; the structural underpinnings of the kinetics & thermodynamics of macromolecular reactions; & the physical basis of important biophysical methods.

Instructor(s): John Gross, James Fraser

This is a team-based class where students work in small groups develop their own analysis of real data that they have collected. Statistical aspects of rigor and reproducibility in structural biology will be emphasized throughout lectures, journal club presentations, and hands-on activities.

Instructor(s): Hani Goodarzi, Luke Gilbert

This course will teach the fundamentals of dissecting and understanding complex biological systems using didactic instruction in addition to practical lab experience in the context of a team based project. For each project, students will learn and use modern genomic and proteomic tools to characterize transcriptional circuits within a model organism. This course is a continuation of material introduced in 205A.

Instructor(s): Orion Weiner

This course provides a comprehensive introduction to light microscopy as it is commonly used for imaging biological samples. No previous experience with microscopy is assumed; the course begins with basic optics and covers the design and operation of modern research microscopes. Advanced techniques including confocal microscopy, TIRF, and super-resolution techniques are covered. This course includes both labs and lectures.

Instructor(s): Staff

An introduction to the specific research currently underway within a faculty member's laboratory.

Instructor(s): Staff

Each course offering will focus on the literature of a current important area of Biophysics. Students will be expected to read assigned papers critically before class and to present and discuss papers in class. Students will also be expected to write and present a brief research proposal based upon their reading. Topics in Molecular, Cellular, Developmental Systems and Computational Biology will be covered in individual courses.

Instructor(s): Alan Frankel

This course consists of presentation and discussion of research in quantitative biology and biophysics by outside speakers.

Instructor(s): Tanja Kortemme

This seminar will provide graduate students with a forum in which to develop seminar and poster presentation skills; critically organize and critically review scientific data; and analyze and question oral scientific presentations.

Instructor(s): Jim Wells, Lani Wu

Critical review of published scientific papers from scholarly journals, including comprehension, analysis and evaluation of published scientific data.

Instructor(s): Michael Grabe

This is a course on molecular thermodynamics and statistical mechanics. It covers the concepts of entropy, enthalpy, heat capacity, free energy, ligand binding, solvation, the properties of water, the hydrophobic effect, solution electrostatics, adsorption, and physical and chemical kinetics.

Instructor(s): Staff

In this course, students will work together with a primary research advisor to select a research question and design a project workplan that will be carried out by the student. Through this activity, the student will gain experience in research strategy, learn techniques associated with modern biomedical research and practice how to interpret results. At the conclusion of the course, the student will present on their progress.

Instructor(s): Zev Gartner

Communicating your best ideas is critical to obtaining the resources necessary to work on them. This course prepares you to conceive, organize, and communicate scientific ideas in written form. Built around the NSF GRF application, this course covers important funding agencies and fellowship opportunities, formulating a research plan in the form of hypotheses and specific aims, organizing research proposals,and peer editing. Course culminates in submission of materials to NSF and other agencies

Instructor(s): Staff

For graduate students engaged in writing the dissertation for the PhD degree.

Instructor(s): Tanja Kortemme

The Curricular Development & Academic Leadership course will offer training and leadership to prepare graduate students in scientific leadership roles in the classroom and beyond. Students will have a hands-on approach to structuring and executing a curriculum. Students must submit an application prior to course enrollment.